Insecticidal Evaluation and Structure-Activity Relationship Study of Some Synthesized Urea and Thiourea Derivatives Against Spodoptera Littoralis (Boisd.)

Document Type : Regular Articles

Authors

1 Plant Protection Research Institute, Agriculture Research Centre, Dokki, Cairo

2 chemistry department, Faculty of Science, Sohag University, Sohag, Egypt

3 Research Institute of Plant Protection, Agricultural Research Center, 12619 Giza, Egypt.

4 Plant Protection Research Institute, Agriculture Research Centre, Dokki,Cairo

5 Chemistry Dept., Faculty of Science Sohag University

10.21608/sjsci.2025.359928.1257

Abstract

Because utilizing insecticides can cause some serious issues, finding safe options to these chemicals has become decisive. So, in order to create novel Hexaflumuron analogues as insect growth regulators that could be screened & tested against Spodoptera littoralis (Boisd), urea and thiourea derivatives that were projected to be toxicologically active were synthesized in pure form. An equimolecular amount of 4-nitroanaline was added with stirring to phenyl isocyanate and phenyl isothiocyanate in dry 1,4-dioxane. By using spectroscopic and elemental investigations, the structure of synthesized substances was determined. Target compounds 3a and 3b had moderate insecticidal toxicity; their LC50 values for the second larval instar were determined to be 147.26 and 316.01 mg/L, respectively, whereas the LC50 value for the reference insecticide, hexaflumuron, was 17.01 mg/L. Finally, this work further demonstrates the anti-proliferation of S. littoralis and discusses how to discover novel target compounds that may one day be employed as effective insecticidal agents.

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