Hematological and antioxidant biomarkers alterations in male albino rats treated with bisphenol A: the protective impact of vitamin E

Document Type : Regular Articles

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Zoology Department, Faculty of Science, Sohag University, Sohag 82524, Egypt

Abstract

Bisphenol-A (BPA) is one of the most environmental pollutants used as industrial polymers for manufacturing plastics. It causes deleterious effects in humans and animals. Vitamin E is a fat-soluble antioxidant that acts as a reactive oxygen species (ROS) scavenger to prevent lipid peroxidation. The present study was aimed to evaluate the beneficial effect of vitamin E on the hematological and antioxidant biomarkers against the toxicity of bisphenol -A after one month in male albino rats. Twenty -four male albino rats were divided into four groups. The first group acts as a control group, the second group was treated with BPA at 30mg/kg body wt., the third group was treated with Vit. E 160mg/kg body wt., and the fourth group was treated with vitamin E along with BPA. The results obtained revealed that BPA induced remarkable alterations, either increase or decrease in the hematological and antioaxidant biomarkers, with respect to the control. Vitamin E combined with BPA induced a marked enhancement on the toxic effect of BPA on the biomarkers examined. So, it can be concluded that each vitamin E and the combination of vitamin E with BPA have beneficial impact in slightly improved but not completely removing the toxic effects of BPA on the hematological and antioxidant biomarkers as a protective effect preventing the damage of hematopiotic organs and the defense mechanism of antioxidants. 

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