Evaluating the effects of anticoagulant rodenticide bromadiolone in wild rats (Rattus rattus frugivorous) co-administered with aspirin on haemostatic, hematological and antioxidant parameters.

Document Type : Regular Articles

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1 Agriculture Research center, Doki, Egypt

2 Zoology Department, Faculty of Science, Sohag University, Sohag 82524, Egypt

3 Plant Protection Department, Faculty of Agriculture, Sohag University, Sohag 82524, Egypt

Abstract

Abstract: The control of rodents which have a negative effect on human health, domestic animals, economic crops and animal poisoning is primarily based on the use of anticoagulant rodenticides. Bromadiolone is a wide-use long-acting anticoagulant rodenticide. Aspirin (Acetylsalicylic acid, ASA) has its biological target, on cyclogenase Enzymes drives various functions including haemostasis and inflammation.
The aim of the present study was to investigate the beneficial effects of bromadiolone and aspirin as anticoagulants on hematological, haemostatic, and antioxidant parameters in wild rats for four days. Twenty-four rats were collected from Shandaweel farm, agricultural research center, Sohag, Egypt. The rats were randomly divided into four groups. The first group acted as a control group, the second group was fed with bromadiolone (0.44 mg/kg b. wt) loaded with wheat grains, the third group was orally treated with ASA (60 mg/kg b. wt), whereas the fourth group was treated with bromadiolone along with aspirin. The main findings showed significant alterations in hematological indices, either increase or decrease, in rats treated with bromadiolone and aspirin, but most of them showed marked decreases. About haemostatic parameters, rats treated with either bromadiolone or ASA and aspirin along with bromadiolone showed a marked increase in all hemostatic parameters. Antioxidant enzyme parameters showed either increase or decrease in the rats treated with bromadiolone, aspirin and aspirin in combination with bromadiolone. The results indicate that the combination of different anticoagulants may provide a successful tool for rodent control and a more environment-friendly method of protection of non-target animals.

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