In this work, we synthesized a novel arylidene malononitrile 3 via the treatment of o-alkyl vanillin derivative 1 with malononitrile 2 in the presence of triethylamine (TEA) as a catalyst. The arylidene malononitrile 3 was subjected to react under one-pot multicomponent reaction (MCR) condition with respective methylarylketones 4a-f and sodium ethoxide 5 in ethanol to afford a new series of 2-(4-(6-aryl-3-cyano-2-ethoxypyridin-4-yl)-2-methoxyphenoxy)-N-phenylacetamides 6a-f. The structure of the new products was assured via spectral and elemental analysis. The reaction mechanism was suggested.
Mohammed, H., Ahmed, E. A., Hussein, B., & Abdellah, O. (2024). One-pot Multicomponent Synthesis of Novel Polyfunctionalized Pyridines. Sohag Journal of Sciences, 9(1), 76-80. doi: 10.21608/sjsci.2023.227734.1111
MLA
Hayam H. Mohammed; Eman A. Ahmed; Bahgat R. M. Hussein; Omran A. Abdellah. "One-pot Multicomponent Synthesis of Novel Polyfunctionalized Pyridines". Sohag Journal of Sciences, 9, 1, 2024, 76-80. doi: 10.21608/sjsci.2023.227734.1111
HARVARD
Mohammed, H., Ahmed, E. A., Hussein, B., Abdellah, O. (2024). 'One-pot Multicomponent Synthesis of Novel Polyfunctionalized Pyridines', Sohag Journal of Sciences, 9(1), pp. 76-80. doi: 10.21608/sjsci.2023.227734.1111
VANCOUVER
Mohammed, H., Ahmed, E. A., Hussein, B., Abdellah, O. One-pot Multicomponent Synthesis of Novel Polyfunctionalized Pyridines. Sohag Journal of Sciences, 2024; 9(1): 76-80. doi: 10.21608/sjsci.2023.227734.1111
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