Hemato-biochemical toxicity induced by Carbendazim and the ameliorative impact of date palm pollen in female albino rats.

Farag, Mohamed; Bd El Aziz Khalil, Heba A; Abdel-Ghaffar, KH; Abas Abdel-Karim, Doaa

doi:10.21608/sjsci.2025.393132.1277

Hemato-biochemical toxicity induced by Carbendazim and the ameliorative impact of date palm pollen in female albino rats.

Document Type : Regular Articles

Authors

¹ Zoology, Science, Sohag

² Zoology Department, Faculty of Science, Sohag University, Sohag 82524, Egypt

³ Department of Pathology and Clinical pathology, Veterinary medicine Faculty, Assiut University

10.21608/sjsci.2025.393132.1277

Abstract

Carbendazim (CARB) is a fungicide used worldwide for crop production and control of different pests and insects. It is a common environmental pollutant that contaminates food and water and severely damages human and animal health. Date palm Pollon (DPP) is an important source of natural antioxidants which is related to the presence of Phytochemicals such as flavonoids, Phenols, and vitamins. The current study aimed to investigate the ameliorative impact of DPP against the toxicity of carbendazim on the hematological parameters and the biomarkers of hepatorenal function for two months in female albino rats. Thirty-two female albino rats were allocated into four groups. The first group acts as a control group, the second group was exposed to 10 mg/kg body wt. of CARB, the third group was exposed to 100 mg/kg body wt. of DPP, whereas the fourth group was exposed to CARB before DPP. The results obtained indicated that DPP normalized the hematological and hepato-renal parameters. However, CARB induced a marked alteration in the hematological parameters and hepato-renal biomarkers. CARB combined with DPP induced a marked improvement, either increase or decrease in the toxicity of CARB on the hematological indices and the biomarkers of hepato-renal functions. So, it can be concluded that each DPP and the combination of CARB along with DPP have a beneficial impact in the improvement of the toxic effect of CARB on hematological indices and biomarkers of hepato-renal functions as an ameliorative impact, preventing the damage of hematopoietic organs and hepato-renal functions.

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