Hematotoxicity induced by thioacetamide and the protective effect of date palm pollens (DPP) and Femara in male albino rats.

Document Type : Regular Articles

Authors

1 Zoology Department, Faculty of Science, Sohag University, Sohag 82524, Egypt

2 Zoology Department, Faculty of Science, Assuit University, Assuit 71515, Egypt

3 Agriculture Research center, Animal Health Institute, Doki, Egypt

Abstract

Thioacetamide (TAA) is an organic compound that is used in rubber and pesticides production. In 1984 Fitzhugh and Nelson provided the first evidence of being a carcinogen. Femara ® (Letrazole) are a synthetic aromatase inhibitor (AIs) used in the treatment of breast cancer which work as competitive inhibitor of aromatase in peripheral tissues. Date palm pollen (DPP) is an important source of natural antioxidant which is largely related to the presence of flavonoids and vitamins. The current study aimed to investigate the interaction impact between DPP and Femara against the toxicity of TAA on the hematological parameters after four months in male albino rats. Seventy-two male albino rats were divided into seven groups. The first group act as a control group, the second group was treated with Femara (50 mg/kg body wt), the third group was treated with 100 mg/kg body wt. of TAA, the fourth group was treated with 100 mg/kg body wt. of DPP, the fifth group was treated with DPP before TAA, the sixth group was treated with DPP before TAA, whereas the seventh group was treated with Femara combined with DPP before TAA. The obtained results indicated that TAA induced a remarkable alteration, either increase or decrease in the hematological parameters relative to that of control. Moreover, DPP and Femara each alone or combined together normalized the hematological indices. So, it can be concluded that combination of Femara and/or DPP along with TAA have a beneficial impact in retarding the hematotoxicity of TAA in male rats.

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