Protective and ameliorative role of date palm pollen and vitamin C against gastric toxicity induced by bisphenol-A in male albino rat

Document Type : Regular Articles

Authors

1 Zoology Department, Faculty of Science, Sohag University, Sohag, Egypt

2 Department of Pathology and Clinical pathology, Veterinary medicine Faculty, Assiut University

3 Department of Zoology, Faculty of Science, Sohag University, Sohag, 52824, Egypt

Abstract

This study evaluated the protective and ameliorative role of date palm pollen and vitamin C against bisphenol- A ( BPA ) induced gastric structure toxicity in rats. control rats received only food and water, Second group administrated BPA ( 30 mg/kg b.wt. ). Third group was given DPP (100 mg/kg b.wt.).Fourth group was given Vit. C (160 mg/kg b.wt.). Fifth group was given DPP 12 hrs before administration of DPP, while the sixth group was given BPA 12 hrs before administration of BPA. The seventh group was given Vit. C 12 hrs before administration of BPA, whereas the eighth group was given BPA 12 hrs before administration of vit. C. The ninth group was given DPP combined with Vit. C 12 hrs before administration of BPA.BPA induced histopathological changes in the stomach indicated by congestion at the vasculatureand edema of the submucosal layer of the non-glandular part, and congestion of the blood vessels at the muscular layer of the glandular part. However, administration of each DPP and vitamin C before and after BPA, or combined with each other before BPA, restored the normal histological structure of the stomach. So, this study revealed that DPP and Vit. C protected and ameliorated gastric structure against BPA toxicity via their antioxidant activities.

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Sohag Journal of Sciences
Volume 7, Issue 3
September 2022
Pages 183-187

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