Acrylamide-Induced Ovarian Toxicity in Female Wistar Albino Rats

Document Type : Regular Articles

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Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt.

Abstract

Acrylamide was well known to induce reproductive toxicity with an impact on reproductive functions on both male and female. The current investigation was designed as a trial to assess any changes in ovarian hormones and histology brought on by the administration of acrylamide for three weeks. Methods: Animals were split into two groups (N = 10) and fed a healthy diet. and DMSO (1%) saline (9%), Acrylamide (AA) group received acrylamide in saline (9%), (20 mg/kg b. w.) for 21days. Alteration in the level of ovarian hormones were assayed and correlated with histological changes in ovarian tissue. Results: Estradiol levels in the serum were considerably increased after acrylamide administration, but progesterone levels were significantly decreased. Histological study revealed that AA causes cyst formation, corpus luteum d generation which pointed to ovarian follicular regression. In conclusion: Results showed that AA modulated hormonal levels in female rats that related to alteration in ovarian structure 

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Sohag Journal of Sciences
Volume 7, Issue 3
September 2022
Pages 111-115

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