Synthesis of Some New Thieno[2,3-b]thiophene Derivatives and Prediction their Biological Activity by PASS INET

El- Remailya, Mahmoud Abd El Aleem Ali Ali; Shokr, Elders Kh.; Abdel-Ghany, H.; Kamel, Moumen S.; Elhady, Omar. M.; Soliman, Ahmed M.

doi:10.21608/sjsci.2022.233419

Synthesis of Some New Thieno[2,3-b]thiophene Derivatives and Prediction their Biological Activity by PASS INET

Document Type : Regular Articles

Authors

Mahmoud Abd El Aleem Ali Ali El- Remailya ¹
Elders Kh. Shokr ²
H. Abdel-Ghany ¹
Moumen S. Kamel ¹
Omar. M. Elhady ¹
Ahmed M. Soliman ¹

¹ Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt

² Physics Department, Faculty of Science, Sohag University, Sohag 82524, Egypt

10.21608/sjsci.2022.233419

Abstract

A series of thieno[2,3-b] thiophene moiety-containing bis-barbituric 2a,b and bis-pyrazoles 3-4a–b derivatives were synthesized and predict their biological activity using PASS INET. According to obtanied data the most frequently predicted, which they showed high biological activity predicted for a potential compound with the highest probability are oxidoreductase inhibitor, chemosensitizer, potassium channel large-conductance Ca-activated activator, Cystinyl aminopeptidase inhibitor and Neurotransmitter uptake inhibitor.

Keywords

Main Subjects

Chemistry

References

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