Utility of Carbothiohydrazides in Synthesis of some New Heterocyclic Compounds with Five- and Six-Membered Rings

Document Type : Regular Articles

Authors

1 Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt

2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, Egypt

Abstract

Abstract: In this work we studied the reaction of carbohydrazides with some reagents having electrophilic centers such as
arylmethylenemalononitrile, aromatic aldehydes, bis(methylthio)methylenemalononitrile, dimethyl acetylene-dicarboxylate
and cyanoguanidine. The resulting products are five-membered heterocyclic rings such as thiadiazoles, thiazoles, triazoles;
and six-membered heterocyclic rings such as triazines.

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